| All times Eastern |
| Week 2 NFL Schedule |
| Sunday, September 20, 2009 |
| | Arizona Cardinals at Jacksonville Jaguars | 9/20/09 1:00 PM |
| | Carolina Panthers at Atlanta Falcons | 9/20/09 1:00 PM |
| | Cincinnati Bengals at Green Bay Packers | 9/20/09 1:00 PM |
| | Houston Texans at Tennessee Titans | 9/20/09 1:00 PM |
| | Minnesota Vikings at Detroit Lions | 9/20/09 1:00 PM |
| | New England Patriots at New York Jets | 9/20/09 1:00 PM |
| | New Orleans Saints at Philadelphia Eagles | 9/20/09 1:00 PM |
| | Oakland Raiders at Kansas City Chiefs | 9/20/09 1:00 PM |
| | St. Louis Rams at Washington Redskins | 9/20/09 1:00 PM |
| | Seattle Seahawks at San Francisco 49ers | 9/20/09 4:05 PM |
| | Tampa Bay Buccaneers at Buffalo Bills | 9/20/09 4:05 PM |
| | Baltimore Ravens at San Diego Chargers | 9/20/09 4:15 PM |
| | Cleveland Browns at Denver Broncos | 9/20/09 4:15 PM |
| | Pittsburgh Steelers at Chicago Bears | 9/20/09 4:15 PM |
| | New York Giants at Dallas Cowboys | 9/20/09 8:20 PM |
| Monday, September 21, 2009 |
| | Indianapolis Colts at Miami Dolphins | 9/21/09 8:30 PM |
| (Bye Weeks: NONE)
|